Researchers found that the immune enzyme TYK2 adds a tag to tau protein, causing toxic buildup in the brain. Blocking TYK2 reduced harmful tau and neuron damage in mice, offering a potential new target for Alzheimer’s treatment.
A study found that following the Mediterranean or DASH diets is linked to better brain function and slower mental decline in older adults, while the MIND diet improved initial cognition but didn't slow cognitive decline over time.
Alzheimer’s disease and alcohol use disorder share similar gene expression changes, including increased inflammation, disrupted brain signaling, and vascular damage, suggesting alcohol use may worsen or accelerate Alzheimer’s progression through shared molecular mechanisms.
Bilingual individuals with Alzheimer’s disease showed preserved hippocampal volume compared to monolinguals, suggesting bilingualism may provide brain maintenance benefits.
A high dose of nicotinamide, tested as a treatment for early-stage Alzheimer’s, showed no significant impact on reducing harmful tau proteins in the brain.
A rare genetic variant, APOE3 Christchurch, delays Alzheimer's onset by years in high-risk individuals, offering insights into disease resilience. This discovery could guide new treatments targeting similar protective pathways for Alzheimer’s prevention and therapy.
Positive sibling relationships in childhood and frequent contact with siblings in adulthood are linked to better cognitive health in old age, according to new research.
Loneliness has been called a public health crisis, and new research suggests the stakes are even higher than we thought.
Black older adults who frequently attend religious services are significantly less likely to develop Alzheimer’s or related dementias, while private religious practices, like prayer, showed no protective effect.
New research suggests Alzheimer's drugs may improve cognition by increasing Aβ42 levels rather than just reducing plaques, challenging the amyloid cascade hypothesis and pointing to new therapeutic strategies focused on restoring soluble Aβ42 to maintain brain health.
Everyday physical activity, even light movement, improves cognitive processing speed, equivalent to reversing four years of cognitive aging. This highlights the short-term brain benefits of staying active.
The MIND diet slows cognitive decline in older adults, with Black participants requiring stricter adherence for benefits. Racial and gender differences suggest broader social, lifestyle, and biological factors influence the diet's effectiveness.
Music therapy improves dementia care by reducing anxiety, agitation, and depression, enhancing mood, memory, and cognitive function. Familiar songs trigger emotional and physical responses, potentially strengthening neural connections and supporting overall wellbeing.
Researchers observed that amyloid-beta and tau proteins are associated with a transition from hyperactivity to slower brain activity, which aligns with declines in attention and memory, suggesting potential early indicators of Alzheimer’s disease progression.
APOE4 carriers had higher blood-brain barrier permeability, even without cognitive decline or amyloid beta buildup, suggesting early vascular changes that may be linked to Alzheimer’s risk and neurodegeneration.